Studies on Analgesics. IV

An update on analgesics.

Recent introduction of new analgesics into the clinic is best described as a slow process with activity classified into two main areas: improving analgesic efficacy/potency and reducing side-effect profile. This review article describes some of the recent advances with an emphasis on use in the acute setting. In this respect, opioids continue to be the mainstay (but not the only) analgesic and ...

Studies on Self-Sterility. IV. Selective Fertilization.

INTRODUCTION .................................................................. 346 Discussion of the problem ..................................................... 348 Pollen-tube frequency distributions ............................................. 349 Influence of growth of compatible pollen tubes upon incompatible pollen tubes.. .. 352 SUMMARY AND DISCUSSION ....................................

Structural studies on human type IV collagen.

Type IV collagen was isolated from limited pepsin digests of human placenta by selective salt precipitation at acidic and neutral pH. The native protein was resistant to human skin collagenase but was cleaved by a rat mast cell protease. Molecular sieve chromatography of the reduced and alkylated material separated relatively homogeneous components of molecular weight 140,000 (140K) and 100,000...

Studies on Plasma Protein. IV. Leprosy

Opioid Analgesics

Intensive research on the neurobiology of pain over the past two decades has revealed many receptors, ion channels and enzymes with potential as novel targets for development of a new generation of analgesic agents. However, despite large investment in preclinical and clinical development of small molecules and biologics as potential novel pain therapeutics, very few have reached the clinic. He...